Publication: New insights into the cytoplasmic function of PML
Authors
Salomoni, P. ; Bellodi, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
PML is a tumour suppressor inactivated in
Acute Promyelocytic Leukaemia (APL). PML is the
essential component of a subnuclear structure called the
PML nuclear body (PML-NB), which is disrupted in
APL. By targeting different cellular proteins to this
structure, PML can either hamper or potentiate their
functions. The PML transcript undergoes alternative
splicing to generate both nuclear and cytoplasmic
isoforms. Most of the research in this field has focused
its attention on studying nuclear PML. Nevertheless,
new exciting studies show that cytoplasmic PML may
control essential cellular functions, thus opening new
avenues for investigation.
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Citation
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