Publication: Adipose-derived stem cells in articular cartilage regeneration: current concepts and optimization strategies
Authors
Gu, Xingjian ; Li, Caixin ; Yin, Feng ; Yang, Guanghua
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-955
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info:eu-repo/semantics/article
Description
Abstract
Knee osteoarthritis (KOA) is the most
common progressive joint disorder associated with
disability in the world. As a chronic disease, KOA has
multifactorial etiology. However, the poor self-healing
ability of the articular cartilage due to its intrinsic tissue
hypovascularity and hypocellularity seems to be directly
incriminated in the physio-pathological mechanism of
KOA. While conventional therapies result in
unfavorable clinical outcomes, regenerative cell
therapies have shown great promise in articular cartilage
regeneration. Adipose-derived stem cells (ASCs) appear
to be an ideal alternative to bone-marrow derived stem
cells (BMSCs) and autologous chondrocytes, due to their
lower immunogenicity, richer source and easier
acquisition. Since the first case report in 2011, ASCs
have demonstrated safety and efficacy for articular
cartilage regeneration in several phase I/II clinical trials.
However, different levels of abnormality were found in
the regenerated cartilage for most of the patients. A large
portion of recent publications investigated different
optimization strategies to improve the therapeutic
function of ASCs, including cell source selection,
preconditioning and co-delivery. Herein, we give an
update on the latest research progress on ASCs, with a
focus on the most promising optimization strategies for
ASC-based therapy.
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Citation
Histology and Histopathology, Vol.33, nÂş7, (2018)
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