Publication: Spermatozoa-li ke cell invaders, nuclear vlimata, in human neoplasia
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Date
1993
Authors
Logothetou-Rella, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Spermatozoa-like cells (nuclear vlimata)
have been identified in malignant cell cultures and
embryonic cells, also common in the cytology and
histology of all types of human neoplasia even after
chemotherapy. A new mechanism of invasion of
malignant cells has been described, according to which
neoplastic cells behave and function as parasites using
host-cells to divide, survive and eventually produce
nuclear vlimata (bullets). Nuclear vlimata are the end
cell products of incomplete, unequal, assymetrical
division of neoplastic cells. The nuclear vlima exhibits
similar morphology to spermatozoa and virus (head
with, or without, tail) and invades the cytoplasm andor
nucleus of surrounding host-cells by a similar
mechanism to sperm-oocyte interaction (fertilization) or
viral cell infection, in the events of nuclear vlima +
tumor + nuclear vlima + tumor.
The nuclear vlima head contains and transfers DNA,
and when incorporated into the host-nucleus is
indistinguishable from nucleoli and when in the
cytoplasm is similar to sperm pronucleus, observed after
sperm penetration of the oocyte. Function of nuclear
vlimata is directly dependent on the specific
extracellular matrix produced by malignant
cells, consisting of glycosaminoglycans-proteasemembranes.
This mechanism of invasion constitutes the
link of all scientific information concerning human
neoplasia.
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