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Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1

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dc.contributor.authorManskikh, V.N.
dc.contributor.authorGancharova, O.S.
dc.contributor.authorNikiforova, A.I.
dc.contributor.authorKrasilshchikova, M.S.
dc.contributor.authorShabalina, I.G.
dc.contributor.authorEgorov, M.V.
dc.contributor.authorKarger, E.M.
dc.contributor.authorMilanovsky, G.E.
dc.contributor.authorSkulachev, V.P.
dc.contributor.authorZinovkin, R.A.
dc.contributor.authorGalkin, I.I.
dc.date.accessioned2020-03-18T12:53:02Z
dc.date.available2020-03-18T12:53:02Z
dc.date.issued2015
dc.description.abstractAge-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxidant SkQ1 retards senescence-associated myocardial disease (cardiomyopathy), cardiac hypertrophy, and diffuse myocardial fibrosis. To investigate the molecular basis of the action of SkQ1, we have applied DNA microarray analysis. The global gene expression profile in heart tissues was not significantly affected by administration of SkQ1. However, we found some small but statistically significant modifications of the pathways related to cellto-cell contact, adhesion, and leukocyte infiltration. Probably, SkQ1-induced decrease in leukocyte and mesenchymal cell adhesion and/or infiltration lead to a reduction in age-related inflammation and subsequent fibrosis. The data indicate a causative role of mitochondrial reactive oxygen species in cardiovascular aging and imply that SkQ1 has poteential as a drug against age-related cardiac dysfunction.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 3 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-30.353
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/88224
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMitochondria-targeted antioxidantes
dc.subjectMyocardial fibrosises
dc.subjectCardiac hypertrophyes
dc.subjectLeukocyte infiltrationes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleAge-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº3 (2015)