Publication:
Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension

Simple item page
dc.contributor.authorNara, S.es
dc.contributor.authorHachisuka, K.es
dc.contributor.authorFurukawa, H.
dc.contributor.authorDoi, Y.
dc.contributor.authorKudo, H.
dc.contributor.authorFujimoto, S.
dc.date.accessioned2011-05-11T10:58:09Z
dc.date.available2011-05-11T10:58:09Z
dc.date.issued2002
dc.description.abstractImmunoreactivity for desmin, plectin and a- actinin was inve s t i gated in rat atrophic soleus muscle fibers induced by hindlimb suspension between 1 and 4 weeks (hindlimb suspension group, HSG), and compared with that of the control group (CG). Some of the HSG for 4 weeks were allowed unrestricted cage activity for 2 weeks as the recovery group (RG). In the cross-sectioned muscle fibers of the CG, desmin and plectin show e d h o n ey-comb immunoreactive patterns ex t e n d i n g throughout the sarcoplasm. Superimposed images by double immunofluorescence labeling show e d overlapping of both immunoreactivities. In the longitudinally sectioned profiles, superimposed images of a-actinin and desmin were overlapped at the level of Z-discs. The focal disorganization of the above honey - comb immunoreactive patterns, followed by the reduction of the cross-sectional area (CSA) of atrophic soleus muscle fibers and the appearance of Z-streaming, uniquely arose in the HSG from the first week and extended throughout the sarcoplasm in proportion to the suspension period. Such honey-comb patterns of both desmin and plectin were already restored in the RG at 2 weeks, followed by the disappearance of Z-streaming, prior to the recovery of the CSA. These findings indicate that the disorganization of topological and structural relationships of desmin and plectin with Z-discs surrounding individual myofibrils is primarily evo ke d , which leads to Z-streaming of atrophic soleus muscle fibers, and that the restoration of the muscle activity results in an early arrangement recovery of desmin and plectin around myofibrils.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20786
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDesmines
dc.subjectMuscle atrophyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomíaes
dc.titleDisorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspensiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Disorganization of honeycomb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension.pdf
Size:
748.47 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.17, nº 2 (2002)