Publication: Disorganization of honey-comb immunoreactive pattern of desmin and plectin in rat atrophic soleus muscle fiber induced by hindlimb suspension
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Date
2002
Authors
Nara, S. ; Hachisuka, K. ; Furukawa, H. ; Doi, Y. ; Kudo, H. ; Fujimoto, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Immunoreactivity for desmin, plectin and a-
actinin was inve s t i gated in rat atrophic soleus muscle
fibers induced by hindlimb suspension between 1 and 4
weeks (hindlimb suspension group, HSG), and compared
with that of the control group (CG). Some of the HSG
for 4 weeks were allowed unrestricted cage activity for 2
weeks as the recovery group (RG). In the cross-sectioned
muscle fibers of the CG, desmin and plectin show e d
h o n ey-comb immunoreactive patterns ex t e n d i n g
throughout the sarcoplasm. Superimposed images by
double immunofluorescence labeling show e d
overlapping of both immunoreactivities. In the
longitudinally sectioned profiles, superimposed images
of a-actinin and desmin were overlapped at the level of
Z-discs. The focal disorganization of the above honey -
comb immunoreactive patterns, followed by the
reduction of the cross-sectional area (CSA) of atrophic
soleus muscle fibers and the appearance of Z-streaming,
uniquely arose in the HSG from the first week and
extended throughout the sarcoplasm in proportion to the
suspension period. Such honey-comb patterns of both
desmin and plectin were already restored in the RG at 2
weeks, followed by the disappearance of Z-streaming,
prior to the recovery of the CSA. These findings indicate
that the disorganization of topological and structural
relationships of desmin and plectin with Z-discs
surrounding individual myofibrils is primarily evo ke d ,
which leads to Z-streaming of atrophic soleus muscle
fibers, and that the restoration of the muscle activity results in an early arrangement recovery of desmin and
plectin around myofibrils.
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