Publication:
Invited Review :(6-4) Photolyase: Light-dependent repair of DNA damage

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dc.contributor.authorZhao, X.es
dc.contributor.authorMu, D.es
dc.date.accessioned2011-02-22T10:59:49Z
dc.date.available2011-02-22T10:59:49Z
dc.date.issued1998
dc.description.abstractDNA photolyase represents a phenomenal class of DNA repair enzymes in that it harvests the light energy to repair DNA lesions caused by ultraviolet light. Mother Nature evolves two types of photolyases, one specific for repairing cyclobutane pyrimidine dimers and the other for pyrimidine-(6-4)-pyrimidone photoproducts. Together, these two kinds of DNA photolesions account for the majority of ultraviolet lightinduced DNA lesions. So far, the basic chemical steps of the enzyme mechanism of the two classes of photolyases appear to be very similar. Therefore, it will be very intersting to uncover the determinants of the different substrate specificity between the two photolyases. In this review, we focus on the discussion of the photolyase specific for repairing pyrimidine-(6-4)-pyrimidone photoproducts mainly because the research of the cyclobutane pyrimidine dimer photolyase has recently been reviewed quite extensively.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19119
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPhotolyasees
dc.subjectDNA repaires
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleInvited Review :(6-4) Photolyase: Light-dependent repair of DNA damagees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 4 (1998)