Publication: Invited Review :(6-4) Photolyase: Light-dependent repair of DNA damage
Authors
Zhao, X. ; Mu, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
DNA photolyase represents a phenomenal
class of DNA repair enzymes in that it harvests the light
energy to repair DNA lesions caused by ultraviolet light.
Mother Nature evolves two types of photolyases, one
specific for repairing cyclobutane pyrimidine dimers and
the other for pyrimidine-(6-4)-pyrimidone photoproducts.
Together, these two kinds of DNA photolesions
account for the majority of ultraviolet lightinduced
DNA lesions. So far, the basic chemical steps of
the enzyme mechanism of the two classes of photolyases
appear to be very similar. Therefore, it will be very
intersting to uncover the determinants of the different
substrate specificity between the two photolyases. In this
review, we focus on the discussion of the photolyase
specific for repairing pyrimidine-(6-4)-pyrimidone
photoproducts mainly because the research of the
cyclobutane pyrimidine dimer photolyase has recently
been reviewed quite extensively.
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