Publication:
Glucose transporter expression in developing fetal lungs and lung neoplasms

Simple item page
dc.contributor.authorIto, T.es
dc.contributor.authorNoguchi, Y.es
dc.contributor.authorUdaka, N.
dc.contributor.authorKitamura, H.
dc.contributor.authorSatoh, S.
dc.date.accessioned2011-02-22T11:09:08Z
dc.date.available2011-02-22T11:09:08Z
dc.date.issued1999
dc.description.abstractGlucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is thought to be an important process in cell proliferation, differentiation and maturation. Active glucose uptake could result in accumulation of glycogen in epithelial cells, and utilization of glycogen could be a critical phenomenon for lung epithelia1 development. In hamsters, although facilitative glucose transporter isoform 1 (GLUTl) and isoform 4 (GLUT4) are not detected in adult lungs, expression of them is detected with immunohistochemical and Western blot analyses in the developing fetal lungs. In human lung carcinomas, GLUTl expression is seen in most cases of lung carcinoma, and is seen especially frequently in squamous cell carcinoma. GLUTl expression in adenocarcinoma of the lung is correlated with reduced cell differentiation, larger tumor size and positive lymph node metastasis. A few cases of lung carcinoma show positive staining for GLUT3 and GLUT4. Thus, expression of some facilitative glucose transporter isoforms is detected in developing fetal epithelium and in lung carcinomas. Overexpression of them could enhance uptake of glucose into these cells, and the increased influx of glucose could be involved in active cell proliferation, which is a common character of the developing lung epithelium and carcinoma.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19193
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectLung carcinomaes
dc.subjectGlucosees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleGlucose transporter expression in developing fetal lungs and lung neoplasmses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Glucose transporter expression in developing fetal lungs and lung neoplasms.pdf
Size:
2.6 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.14, nº 3 (1999)