Publication: Glucose transporter expression in developing fetal lungs and lung neoplasms
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Date
1999
Authors
Ito, T. ; Noguchi, Y. ; Udaka, N. ; Kitamura, H. ; Satoh, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Glucose uptake and metabolism are essential
for proliferation and survival of cells, and are supposed
to be enhanced in actively proliferating cell systems such
as embryonic and cancer tissues. Glucose uptake is
usually carried out through glucose transporters.
In the developing fetal lung, metabolism of glucose
is thought to be an important process in cell proliferation,
differentiation and maturation. Active glucose
uptake could result in accumulation of glycogen in
epithelial cells, and utilization of glycogen could be a
critical phenomenon for lung epithelia1 development. In
hamsters, although facilitative glucose transporter
isoform 1 (GLUTl) and isoform 4 (GLUT4) are not
detected in adult lungs, expression of them is detected
with immunohistochemical and Western blot analyses in
the developing fetal lungs.
In human lung carcinomas, GLUTl expression is
seen in most cases of lung carcinoma, and is seen
especially frequently in squamous cell carcinoma.
GLUTl expression in adenocarcinoma of the lung is
correlated with reduced cell differentiation, larger tumor
size and positive lymph node metastasis. A few cases of
lung carcinoma show positive staining for GLUT3 and
GLUT4.
Thus, expression of some facilitative glucose
transporter isoforms is detected in developing fetal
epithelium and in lung carcinomas. Overexpression of them could enhance uptake of glucose into these cells,
and the increased influx of glucose could be involved in
active cell proliferation, which is a common character of
the developing lung epithelium and carcinoma.
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