Publication:
Therapeutic potential of CD73+ mesenchymal stem cells for myocardial infarction and beyond

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dc.contributor.authorHou, Huifang
dc.contributor.authorZheng, Miaoyun
dc.contributor.authorPan, Kai
dc.contributor.authorWang, Guodong
dc.contributor.authorLi, Zongjin
dc.contributor.authorLi, Qiong
dc.contributor.departmentBiología Celular e Histologíaes
dc.date.accessioned2025-07-07T10:35:42Z
dc.date.available2025-07-07T10:35:42Z
dc.date.issued2025
dc.description.abstractExtracellular adenine nucleotides serve as crucial signaling molecules and influence a broad spectrum of physiological and pathological processes. CD73, the rate-limiting enzyme in the metabolism of extracellular adenine nucleotides, is ubiquitously expressed on various cell types, particularly stem cells. CD73+ mesenchymal stem cells (MSCs) have emerged as promising candidates for therapeutic applications due to their immunomodulatory and pro-regenerative properties. Numerous studies have highlighted the crucial role of CD73 in mediating tissue protection in myocardial infarction (MI). In this review, a brief overview of the cell type-specific expression, regulatory effects of CD73 on MSCs, and proangiogenic and immunomodulatory mechanisms is provided, with a focus on current findings concerning the protective functions of CD73 in the context of MI within the framework of stem cell therapyes
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dc.format.extent11es
dc.identifier.citationHistology and Histopathology Vol. 40, nº07 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-859
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/157042
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMesenchymal stem cells (MSCs)es
dc.subjectMyocardial infarction (MI)es
dc.subjectAngiogenesises
dc.subjectImmune regulationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTherapeutic potential of CD73+ mesenchymal stem cells for myocardial infarction and beyondes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº7 (2025)