Publication:
Therapeutic potential of CD73+ mesenchymal stem cells for myocardial infarction and beyond

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Hou-40-993-1003-2025.pdf(2.56 MB)
Date
2025
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Authors
Hou, Huifang ; Zheng, Miaoyun ; Pan, Kai ; Wang, Guodong ; Li, Zongjin ; Li, Qiong
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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Biología Celular e Histología
DOI
https://doi.org/10.14670/HH-18-859
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info:eu-repo/semantics/article
Description
Abstract
Extracellular adenine nucleotides serve as crucial signaling molecules and influence a broad spectrum of physiological and pathological processes. CD73, the rate-limiting enzyme in the metabolism of extracellular adenine nucleotides, is ubiquitously expressed on various cell types, particularly stem cells. CD73+ mesenchymal stem cells (MSCs) have emerged as promising candidates for therapeutic applications due to their immunomodulatory and pro-regenerative properties. Numerous studies have highlighted the crucial role of CD73 in mediating tissue protection in myocardial infarction (MI). In this review, a brief overview of the cell type-specific expression, regulatory effects of CD73 on MSCs, and proangiogenic and immunomodulatory mechanisms is provided, with a focus on current findings concerning the protective functions of CD73 in the context of MI within the framework of stem cell therapy
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Mesenchymal stem cells (MSCs) , Myocardial infarction (MI) , Angiogenesis , Immune regulation
Citation
Histology and Histopathology Vol. 40, nº07 (2025)
URI
http://hdl.handle.net/10201/157042
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Histology and histopathology Vol.40, nº7 (2025)
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