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Extracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeutics

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dc.contributor.authorBavuso, Matthew
dc.contributor.authorMiller, Noel
dc.contributor.authorSill, Joshua M.
dc.contributor.authorDobrian, Anca
dc.contributor.authorColunga Biancatelli, Ruben M.L.
dc.date.accessioned2024-01-23T12:52:04Z
dc.date.available2024-01-23T12:52:04Z
dc.date.issued2024
dc.description.abstractAcute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more thorough understanding of the variegated and cell-specific functions of EVs may lead to the development of safe and effective therapeutics. In this review, we have collected evidence of EVs role in ARDS, revise the main mechanisms of production and internalization and summarize the current therapeutical approaches that have shown the ability to modulate EV signaling.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and Histopathology, Vol.39, nÂş2, (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-659
dc.identifier.urihttp://hdl.handle.net/10201/137598
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAcute respiratory distress syndrome (ARDS)es
dc.subjectAcute Lung Injury (ALI)es
dc.subjectExtracellular vesicles (EVs)es
dc.subjectAlveolo-capillary permeabilityes
dc.subjectTherapeutics, EVs biogenesises
dc.subjectEVs internalizationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleExtracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeuticses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nÂş2 (2024)