Publication: Extracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeutics
Authors
Bavuso, Matthew ; Miller, Noel ; Sill, Joshua M. ; Dobrian, Anca ; Colunga Biancatelli, Ruben M.L.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
https://doi.org/10.14670/HH-18-659
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info:eu-repo/semantics/article
Description
Abstract
Acute respiratory distress syndrome (ARDS)
is a severe respiratory condition characterized by
increased lung permeability, hyper-inflammatory state,
and fluid leak into the alveolar spaces. ARDS is a
heterogeneous disease, with multiple direct and indirect
causes that result in a mortality of up to 40%. Due to the
ongoing Covid-19 pandemic, its incidence has increased
up to ten-fold. Extracellular vesicles (EVs) are small
liposome-like particles that mediate intercellular
communication and play a major role in ARDS
pathophysiology. Indeed, they participate in endothelial
barrier dysfunction and permeability, neutrophil, and
macrophage activation, and also in the development of a
hypercoagulable state. A more thorough understanding
of the variegated and cell-specific functions of EVs may
lead to the development of safe and effective
therapeutics. In this review, we have collected evidence
of EVs role in ARDS, revise the main mechanisms of
production and internalization and summarize the
current therapeutical approaches that have shown the
ability to modulate EV signaling.
Citation
Histology and Histopathology, Vol.39, nÂş2, (2024)
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