Publication: Haemangioblastoma, Histological and immunohistological study of an enigmatic cerebellar tumour
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Date
1990
Authors
Cruz-Sánchez, F. F. ; Rossi, M.L. ; Rodríguez-Prados, S. ; Nakamura, N. ; Hughes, J.T. ; Coakham, H.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Paraffin-embedded blocks of 36 cerebellar
haemangioblastomas were reacted with a panel of
antibodies including glial fibrillary acidic protein,
vimentin, epithelial membrane antigen, cytokeratin,
Factor VIII, a neuroendocrine marker and with Ulex
europaeus. agglutinin The main histological features,
apart from the characteristic large abnormal vessels,
were a prominent reticulin network, a cystic architecture
and cellular and nuclear polymorphism. Two cell types
were identified: endothelial and stromal. Twenty
tumours were positive for glial fibrillary acidic protein
because of included or reactive astrocytes as well as
positive stromal cells. Vimentin was positive in all
tumours with a diffuse distribution and a somatic
pattern; blood vessels, stromal cells and reactive
astrocytes were strongly positive. Factor V111 and Ulex
europaeus agglutinin reactivity were present in a similar
pattern of staining in endothelium and in five cases there
were stromal cells that were positive with the latter.
We were not able to ascertain the histogenesis of the
stromal cell, which remains enigmatic.
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