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Hypoxia-induced Factor-1α in endometrial carcinoma: a mini-review of current evidence

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dc.contributor.authorDousias, Vassilis
dc.contributor.authorVrekoussis, Thomas
dc.contributor.authorNavrozoglou, Iordanis
dc.contributor.authorPaschopoulos, Minas
dc.contributor.authorStefos, Theodore
dc.contributor.authorMakrigiannakis, Antonis
dc.contributor.authorJeschke, Udo
dc.date.accessioned2017-11-07T15:56:37Z
dc.date.available2017-11-07T15:56:37Z
dc.date.issued2012
dc.description.abstractDespite the well-established role of hypoxia in cancer biology, the literature on its effects on endometrial cancer is scarce; it mainly refers to experimental settings rather than patient-derived results. Herein, an overview of the hypoxia inducible factor 1α (HIF-1α) biology, focusing on endometrial cancer, is presented. The molecular mechanisms possibly involved in endometrial cancer progression are presented, followed by a systematic approach to the current literature on immunohistochemistry evaluation of HIF-1α expression in endometrial carcinoma. Since no consensus has been made regarding HIF-1α evaluation, the evidence of possible involvement of HIF-1α in endometrial carcinoma prognosis is weak. After a consensus has been made, properly powered studies may be able to clarify whether HIF-1α can act as a prognosticator in endometrial carcinoma.es
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dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 10 (2012)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/54445
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEndometrial canceres
dc.subjectHypoxiaes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleHypoxia-induced Factor-1α in endometrial carcinoma: a mini-review of current evidencees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº10 (2012)