Publication: Hypoxia-induced Factor-1α in endometrial carcinoma: a mini-review of current evidence
Authors
Dousias, Vassilis ; Vrekoussis, Thomas ; Navrozoglou, Iordanis ; Paschopoulos, Minas ; Stefos, Theodore ; Makrigiannakis, Antonis ; Jeschke, Udo
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Despite the well-established role of hypoxia in cancer biology, the literature on its effects on endometrial cancer is scarce; it mainly refers to experimental settings rather than patient-derived results. Herein, an overview of the hypoxia inducible factor 1α (HIF-1α) biology, focusing on endometrial cancer, is presented. The molecular mechanisms possibly involved in endometrial cancer progression are presented, followed by a systematic approach to the current literature on immunohistochemistry evaluation of HIF-1α expression in endometrial carcinoma. Since no consensus has been made regarding HIF-1α evaluation, the evidence of possible involvement of HIF-1α in endometrial carcinoma prognosis is weak. After a consensus has been made, properly powered studies may be able to clarify whether HIF-1α can act as a prognosticator in endometrial carcinoma.
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Citation
Histology and histopathology, Vol. 27, nº 10 (2012)
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