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Review of renal carcinoid tumor with focus on clinical and pathobiological aspects

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dc.contributor.authorKuroda, Naoto
dc.contributor.authorTanaka, Azusa
dc.contributor.authorOhe, Chisato
dc.contributor.authorMikami, Shuji
dc.contributor.authorNagashima, Yoji
dc.contributor.authorInoue, Keiji
dc.contributor.authorShuin, Taro
dc.contributor.authorTaguchi, Takahiro
dc.contributor.authorTominaga, Akira
dc.contributor.authorAlvarado-Cabrero, Isabel
dc.contributor.authorPetersson, Fredrik
dc.contributor.authorBrunelli, Matteo
dc.contributor.authorMichal, Michal
dc.contributor.authorHes, Ondrej
dc.date.accessioned2018-02-09T15:46:31Z
dc.date.available2018-02-09T15:46:31Z
dc.date.issued2013
dc.description.abstractRenal carcinoid tumor is a rare neoplasm. In this article, we review this neoplasm with a focus on clinical and pathobiological aspects. The majority of patients present in the fourth to seventh decades, but there is no gender predilection. Clinically, patients with renal carcinoid tumor frequently present with abdominal, back or flank pain. This tumor is occassionally associated with horseshoe kidney and/or mature cystic teratoma located in the kidney. Macroscopically, these tumors are well demarcated with a lobulated appearance and yellow or tan-brown color cut surface. Microscopically, these tumors are composed of monomorphic round to polygonal cells with granular amphophilic to eosinophilic cytoplasm. Tumor cells are arranged in trabecular, ribbon-like, gyriform, insular, glandular and solid patterns. The nuclei are round to oval and with evenly distributed nuclear chromatin, frequently with a “salt and pepper”-pattern. Immunohistochemically, tumor cells demonstrate immunolabeling for chromogranin A and synaptophysin. Ultrastructurally, the neoplastic cells contain abundant dense core neurosecretory granules. In previous genetic studies, abnormalities of chromosomes 3 or 13 have been reported. The clinical behavior of renal carcinoid tumors is variable, but is more indolent than most renal cell carcinomas. Further investigations are warranted in order to elucidate the critical genetic abnormalities responsible for the pathogenesis of this rare entity in renal neoplastic pathology.es
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dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 1 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/56009
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRenal carcinoid tumores
dc.subjectPathologyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleReview of renal carcinoid tumor with focus on clinical and pathobiological aspectses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 1 (2013)