Publication: Review of renal carcinoid tumor with focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Tanaka, Azusa ; Ohe, Chisato ; Mikami, Shuji ; Nagashima, Yoji ; Inoue, Keiji ; Shuin, Taro ; Taguchi, Takahiro ; Tominaga, Akira ; Alvarado-Cabrero, Isabel ; Petersson, Fredrik ; Brunelli, Matteo ; Michal, Michal ; Hes, Ondrej
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Renal carcinoid tumor is a rare neoplasm. In
this article, we review this neoplasm with a focus on
clinical and pathobiological aspects. The majority of
patients present in the fourth to seventh decades, but
there is no gender predilection. Clinically, patients with
renal carcinoid tumor frequently present with abdominal,
back or flank pain. This tumor is occassionally
associated with horseshoe kidney and/or mature cystic
teratoma located in the kidney. Macroscopically, these
tumors are well demarcated with a lobulated appearance
and yellow or tan-brown color cut surface.
Microscopically, these tumors are composed of
monomorphic round to polygonal cells with granular
amphophilic to eosinophilic cytoplasm. Tumor cells are
arranged in trabecular, ribbon-like, gyriform, insular,
glandular and solid patterns. The nuclei are round to oval
and with evenly distributed nuclear chromatin,
frequently with a “salt and pepper”-pattern. Immunohistochemically,
tumor cells demonstrate immunolabeling
for chromogranin A and synaptophysin.
Ultrastructurally, the neoplastic cells contain abundant
dense core neurosecretory granules. In previous genetic
studies, abnormalities of chromosomes 3 or 13 have
been reported. The clinical behavior of renal carcinoid
tumors is variable, but is more indolent than most renal
cell carcinomas. Further investigations are warranted in
order to elucidate the critical genetic abnormalities
responsible for the pathogenesis of this rare entity in
renal neoplastic pathology.
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Citation
Histology and histopathology, Vol. 28, n.º 1 (2013)
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