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FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type

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dc.contributor.authorEspinet, Blanca
dc.contributor.authorGarcía-Herrera, Adriana
dc.contributor.authorGallardo, Fernando
dc.contributor.authorBaró, Cristina
dc.contributor.authorSalgado, Rocio
dc.contributor.authorServitje, Octavio
dc.contributor.authorEstrach, Teresa
dc.contributor.authorColomo, Lluis
dc.contributor.authorRomagosa, Vicenç
dc.contributor.authorBarranco, Carlos
dc.contributor.authorSerrano, Sergi
dc.contributor.authorCampo, Elías
dc.contributor.authorPujol, Ramón M.
dc.contributor.authorSolé, Francesc
dc.date.accessioned2016-02-08T18:49:50Z
dc.date.available2016-02-08T18:49:50Z
dc.date.issued2011
dc.description.abstractFOXP1 protein is expressed in normal activated B cells and overexpressed in a subset of diffuse large B-cell lymphomas, including primary cutaneous large B-cell lymphomas (PCLBCL), leg type. High expression of FOXP1 has been associated to an unfavourable prognosis with independent survival significance. However, little is known regarding the mechanisms underlying the overexpression of FOXP1 in PCLBCL, leg type. Our aims were to analyze FOXP1 cytogenetic status and protein expression in a series of PCLBCL, leg type. Finally, we compared the observed results with those obtained in a group of patients with primary cutaneous follicle centre lymphoma (PCFCL). Fifteen patients with PCLBCL, leg type and nine patients with primary cutaneous follicle centre lymphoma (PCFCL) were included in the study. For each biopsy specimen, FOXP1 translocation and copy number changes were evaluated by fluorescence in situ hybridization (FISH) and protein expression by immunohistochemistry (IHC). Immunohistochemistry showed FOXP1 staining in 13 PCLBCL, leg type, whereas all PCFCL were negative. FISH analysis disclosed no translocations involving FOXP1 gene in any of the cases. However, FOXP1 gene gains (3 to 4 copies) were observed in 82% of samples of PCLBCL, leg type and in 37% of PCFCL. FOXP1 expression was independent from FOXP1 translocation. Our results confirm that overexpression of FOXP1 is present in a considerable proportion of PCLBCL, leg type and might indicate an unfavourable prognosis. Mechanisms not related to translocation seem to be responsible for this overexpression.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/47804
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 2 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCutaneous lymphomaes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleFOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-typees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº2 (2011)