Publication: FOXP1 molecular cytogenetics and
protein expression analyses in primary
cutaneous large B cell lymphoma, leg-type
Authors
Espinet, Blanca ; García-Herrera, Adriana ; Gallardo, Fernando ; Baró, Cristina ; Salgado, Rocio ; Servitje, Octavio ; Estrach, Teresa ; Colomo, Lluis ; Romagosa, Vicenç ; Barranco, Carlos ; Serrano, Sergi ; Campo, Elías ; Pujol, Ramón M. ; Solé, Francesc
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
FOXP1 protein is expressed in normal
activated B cells and overexpressed in a subset of diffuse
large B-cell lymphomas, including primary cutaneous
large B-cell lymphomas (PCLBCL), leg type. High
expression of FOXP1 has been associated to an
unfavourable prognosis with independent survival
significance. However, little is known regarding the
mechanisms underlying the overexpression of FOXP1 in
PCLBCL, leg type. Our aims were to analyze FOXP1
cytogenetic status and protein expression in a series of
PCLBCL, leg type. Finally, we compared the observed
results with those obtained in a group of patients with
primary cutaneous follicle centre lymphoma (PCFCL).
Fifteen patients with PCLBCL, leg type and nine
patients with primary cutaneous follicle centre
lymphoma (PCFCL) were included in the study. For
each biopsy specimen, FOXP1 translocation and copy
number changes were evaluated by fluorescence in situ
hybridization (FISH) and protein expression by
immunohistochemistry (IHC).
Immunohistochemistry showed FOXP1 staining in
13 PCLBCL, leg type, whereas all PCFCL were
negative. FISH analysis disclosed no translocations
involving FOXP1 gene in any of the cases. However,
FOXP1 gene gains (3 to 4 copies) were observed in 82%
of samples of PCLBCL, leg type and in 37% of PCFCL.
FOXP1 expression was independent from FOXP1
translocation. Our results confirm that overexpression of FOXP1 is
present in a considerable proportion of PCLBCL, leg
type and might indicate an unfavourable prognosis.
Mechanisms not related to translocation seem to be
responsible for this overexpression.
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