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A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception

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dc.contributor.authorCavallari, Nicola
dc.contributor.authorFrigato, Elena
dc.contributor.authorVallone, Daniela
dc.contributor.authorFroehlich, Nadine
dc.contributor.authorLópez Olmeda, José Fernando
dc.contributor.authorFoa, Augusto
dc.contributor.authorBerti, Roberto
dc.contributor.authorSánchez Vázquez, Francisco Javier
dc.contributor.authorBertolucci, Cristiano
dc.contributor.authorFoulkes, Nicholas Simon
dc.contributor.departmentFisiología
dc.date.accessioned2024-02-09T11:28:09Z
dc.date.available2024-02-09T11:28:09Z
dc.date.issued2011
dc.description©<2011>. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/ccby /4.0/ This document is the published version of a Published Work that appeared in final form in [PLoS Biology]. To access the final edited and published work see [https://doi.org/10.1371/journal.pbio.1001142]
dc.description.abstractThe circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.
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dc.format.extent13
dc.identifier.citationPLoS Biol 9(9): e1001142, 2011
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.1001142
dc.identifier.issnPrint: 1544-9173
dc.identifier.issnElectrónico: 1545-7885
dc.identifier.urihttp://hdl.handle.net/10201/139096
dc.languageenges
dc.publisherPublic Library of Science
dc.relationThis work was supported by funding from the Max-Planck-Institute for Developmental Biology, Tübingen, Karlsruhe Institute of Technology (KIT, Germany), the CNRS (France), the University of Ferrara (Italy), MIUR (PRIN2008), the VIGONI program of the DAAD, and the AIT-MIUR, and the MICINN (Spain) projects CRONOSOLEA and AQUAGENOMICS. JFLO has a postdoctoral fellowship from Fundacion Seneca (Murcia, Spain).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreceptiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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