Publication: A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception
Authors
Cavallari, Nicola ; Frigato, Elena ; Vallone, Daniela ; Froehlich, Nadine ; López Olmeda, José Fernando ; Foa, Augusto ; Berti, Roberto ; Sánchez Vázquez, Francisco Javier ; Bertolucci, Cristiano ; Foulkes, Nicholas Simon
item.page.secondaryauthor
item.page.director
Publisher
Public Library of Science
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1371/journal.pbio.1001142
item.page.type
info:eu-repo/semantics/article
Description
©<2011>. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/ccby /4.0/
This document is the published version of a Published Work that appeared in final form in [PLoS Biology]. To access the final edited and published work see [https://doi.org/10.1371/journal.pbio.1001142]
Abstract
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for
deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here
we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed
to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish
retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by
light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as
essential upstream elements of the peripheral clock light input pathway.
publication.page.subject
Citation
PLoS Biol 9(9): e1001142, 2011
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/