Publication: Mechanism of experimental autoimmune
neuritis in Lewis rats: the dual role of macrophages
Authors
Shin, Taekyun ; Ahn, Meejung ; Matsumoto, Yoh ; Moon, Changjong
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human peripheral demyelinating diseases,
such as Guillain-Barré syndrome (GBS), are
characterized by inflammation and demyelination in the
peripheral nervous system. Similarities in the pathology
between GBS and the animal model of experimental
autoimmune neuritis (EAN) indicate that autoimmune
responses are involved in both diseases. This article
summarizes the general aspects of the EAN model in
Lewis rats and discusses the potential role of
macrophages in the progression of EAN. A better
understanding of macrophages may help to design
alternative therapeutic strategies for organ-specific
autoimmune diseases, including GBS.
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Citation
Histology and Histopathology, vol. 28, nº 6, (2013)
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