Publication: Diagnosis of Hodgkin`s disease: an update on histopathological and immunophenotypical features
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Date
2007
Authors
Fraga, M. ; Forteza, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Hodgkin lymphoma (HL) is a B-cell
lymphoma, as was proved by molecular studies with
single-cell PCR. Histologically, it is characterized by a
minority of neoplastic cells, Reed-Sternberg cells and its
variants, related to a variable non-neoplastic
inflammatory background. Nowadays, (WHO
classification) the following types of HL are recognized:
Nodular Paragranuloma and the Classical Hodgkin
Lymphoma, the latter including Nodular Sclerosis,
Mixed Cellularity, Lymphocyte-rich Classical Hodgkin
Lymphoma and Lymphocyte Depletion. Morphology
together with immunohistochemical studies allows to
classify the different forms of Hodgkin lymphoma and to
make a differential diagnosis with non-Hodgkin
lymphomas. All classical Hodgkin lymphomas are
treated similarly, and chances for remission and survival
are currently good. Molecular parameters should be
added to the current classification and patients could
benefit from new therapeutic targets.
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