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Stimulation of regenerative blastema formation in lizards as a model to analyze limb regeneration in amniotes

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dc.contributor.authorAlibardi, Lorenzo
dc.date.accessioned2022-10-19T09:00:24Z
dc.date.available2022-10-19T09:00:24Z
dc.date.issued2019
dc.description.abstractThe hypothesis here presented tries to explain why organ regeneration is present in fish and amphibians (anamniotes) but is absent in reptiles, birds and mammals (amniotes). Anamniotes possess complex life cycles including larvae and metamorphosis stages, the latter representing a physiological form of organ destruction and regeneration coded in their genome that can be reactivated in adults in the form of regeneration. Part of the genome for larvae and metamorphosis phases was likely lost in amniotes with the evolution of direct development, the potentiation of the immune system and the increase in complexity of the nervous system. These events consequently determined incapability for organ regeneration in extant amniotes with the exception of the lizard tail. This likely derives from the evolution of a mechanism of immunosuppression that allows the regeneration of the tail although the complete morphogenetic plane of tail embryogenesis is lost. The lizard model of imperfect but outstanding organ regeneration indicates the possibility to improve organ regeneration also in other amniotes. In fact, the induction of a blastema in the amputated lizard limb has stimulated the formation of short limbs containing cartilaginous bones of the femur, tibia and fibula, and these experiments foster some hope for future attempts to induce limb and digit regeneration also in mammals.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.34, nÂş10, (2019)
dc.identifier.doihttps://doi.org/10.14670/HH-18-123
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/124665
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnamnioteses
dc.subjectMetamorphosises
dc.subjectAmnioteses
dc.subjectRegenerationes
dc.subjectEvolutiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleStimulation of regenerative blastema formation in lizards as a model to analyze limb regeneration in amnioteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34,nÂş10 (2019)