Publication: Morphological changes induced by colchicine in the chick optic cup in early stages of development. A stereological study
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Date
1999
Authors
Abadía Molina, F. ; Calvente, R. ; Carmona Martos, R. ; Luján, R. ; Abadía Fenoll, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this study chick embryo optic cups at HH
stage 13 of development were analyzed under normal
conditions and after inoculation with colchicine for 1, 2,
4, and 8 h. Several changes were seen after these periods
of treatment: 1) modifications of the structure, with
thicker regions in the cup and a general decrease in the
total volume according to the duration of exposure to the
drug (about 4 times less than normal, 5,035 x lo3 ym3 vs
1,334 x lo3 ym3 after 8 h of treatrnent); 2) enlargement
of the ventricular cavity and its closure, due to failure of
approximation of retina1 and pigmentary layers; 3)
failure of lens development, with delay and impairment
of pit formation and deformation of al1 structures; lens
volume was less than normal (about 4 times less, 2,148 x
103 pm3 vs 658 x lo3 pm3. after 8 h of treatment); 4) a
general segregation of the cells making up the structure,
principally in the more active proliferating zones. The
local alterations found are described
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