Bioactive potential and spectroscopical characterization of a novel family of
plant pigments betalains derived from dopamine

Henarejos Escudero, Paula; Hernández García, Samanta; Martínez Rodríguez, Pedro; Gandía Herrero, Fernando; García Carmona, Francisco

Publication:
Bioactive potential and spectroscopical characterization of a novel family of plant pigments betalains derived from dopamine

dc.contributor.author	Henarejos Escudero, Paula
dc.contributor.author	Hernández García, Samanta
dc.contributor.author	Martínez Rodríguez, Pedro
dc.contributor.author	Gandía Herrero, Fernando
dc.contributor.author	García Carmona, Francisco
dc.contributor.department	Bioquímica y Biología Molecular "A"
dc.date.accessioned	2025-05-15T09:31:20Z
dc.date.available	2025-05-15T09:31:20Z
dc.date.issued	2022-09-22
dc.description	© 2022 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Food Research International. To access the final edited and published work see https://doi.org/10.1016/j.foodres.2022.111956	es
dc.description.abstract	With two compounds first discovered in quinoa, an entire novel family of betalain pigments derived from dopamine is obtained and characterized. Betalains are nitrogenous water-soluble pigments and bioactive molecules with health-promoting effects and nutraceutical potential. It was assumed that all betalains contained betalamic acid as a structural unit derived from L-dihydroxyphenylalanine (L-DOPA). However, hitherto ignored compounds derived from dopamine have recently been discovered in nature. Here an entire family of betalains is described as decarboxylated pigments where 6-decarboxy-betalamic acid is the chromophoric and structural unit. This paper shows for the first time the production, purification and characterization of color and fluorescent properties of this novel family of pigments. Antioxidant and anti-aging effects of the just discovered betalains were tested in vivo using the animal model Caenorhabditis elegans. Some of them presented extraordinary properties, being glutamic acid-6-decarboxy-betaxanthin the most fluorescent molecule among both families of betalains. Methionine sulfoxide-6-decarboxy-betaxanthin is described as the most potent betalain in the reduction of oxidative stress in vivo in C. elegans (99.5 % at 25 µM) and dopa-6-decarboxy-betaxanthin increased the lifespan of the animal model up to 7.0 % at 25 µM. These results open new research lines in the search for molecules from plants with health-promoting properties and bioactivities.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Food Research International 162 (2022) 111956
dc.identifier.doi	https://doi.org/10.1016/j.foodres.2022.111956
dc.identifier.issn	Print: 0963-9969
dc.identifier.issn	Electronic: 1873-7145
dc.identifier.uri	http://hdl.handle.net/10201/154687
dc.language	eng	es
dc.publisher	Elsevier
dc.relation	This work was supported by ‘Ministerio de Ciencia e Innovación’, project PID2021-122896NB-I00 (MCI/AEI/10.13039/501100011033/ FEDER, UE). P.H.-E. holds a contract financed by University of Murcia, Spain. P. M.-R. holds a contract financed by Fundación Séneca, Spain (21587/FPI/21).	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0963996922010146?via%3Dihub
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Antioxidant	es
dc.subject	C. elegans	es
dc.subject	Decarboxylated betalains	es
dc.subject	Lifespan	es
dc.subject	Nutraceutical	es
dc.subject	Quinoa	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	Bioactive potential and spectroscopical characterization of a novel family of plant pigments betalains derived from dopamine	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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