Publication: Bioactive potential and spectroscopical characterization of a novel family of
plant pigments betalains derived from dopamine
Authors
Henarejos Escudero, Paula ; Hernández García, Samanta ; Martínez Rodríguez, Pedro ; Gandía Herrero, Fernando ; García Carmona, Francisco
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.foodres.2022.111956
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info:eu-repo/semantics/article
Description
© 2022 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0
license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Food Research International. To access the final edited and published work see https://doi.org/10.1016/j.foodres.2022.111956
Abstract
With two compounds first discovered in quinoa, an entire novel family of betalain pigments derived from dopamine is obtained and characterized. Betalains are nitrogenous water-soluble pigments and bioactive molecules with health-promoting effects and nutraceutical potential. It was assumed that all betalains contained betalamic acid as a structural unit derived from L-dihydroxyphenylalanine (L-DOPA). However, hitherto ignored
compounds derived from dopamine have recently been discovered in nature. Here an entire family of betalains is described as decarboxylated pigments where 6-decarboxy-betalamic acid is the chromophoric and structural unit. This paper shows for the first time the production, purification and characterization of color and fluorescent properties of this novel family of pigments. Antioxidant and anti-aging effects of the just discovered betalains were tested in vivo using the animal model Caenorhabditis elegans. Some of them presented extraordinary properties, being glutamic acid-6-decarboxy-betaxanthin the most fluorescent molecule among both families of betalains. Methionine sulfoxide-6-decarboxy-betaxanthin is described as the most potent betalain in the reduction of oxidative stress in vivo in C. elegans (99.5 % at 25 µM) and dopa-6-decarboxy-betaxanthin increased the lifespan of the animal model up to 7.0 % at 25 µM. These results open new research lines in the search for molecules from plants with health-promoting properties and bioactivities.
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Citation
Food Research International 162 (2022) 111956
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