Selection events in directing B cell development

Publication:
Selection events in directing B cell development

dc.contributor.author	Seagal, J.	es
dc.contributor.author	Melamed, D.	es
dc.date.accessioned	2011-06-08T09:03:01Z
dc.date.available	2011-06-08T09:03:01Z
dc.date.issued	2003
dc.description.abstract	Homeostasis in the B cell compartment (as well as in T cells) is controlled by tightly regulated selection events. Throughout their life span, B cells are subjected to selection signals determining not only developmental progression, but also maturation and survival. It is now clear that most of these signals require the expression of B cell antigen receptor (or preB receptor) with functional signaling capacity. The administration of numerous mutations into the mouse germline enabled us to identify several checkpoints along the B cell developmental pathway, and provided us with powerful experimental tools to probe for selection events regulating developmental progression. In here, we will discuss recent studies in this field.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/21433
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Positive selection	es
dc.subject	Negative selection	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Selection events in directing B cell development	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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