Publication: Selection events in directing B cell development
Authors
Seagal, J. ; Melamed, D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Homeostasis in the B cell compartment (as
well as in T cells) is controlled by tightly regulated
selection events. Throughout their life span, B cells are
subjected to selection signals determining not only
developmental progression, but also maturation and
survival. It is now clear that most of these signals require
the expression of B cell antigen receptor (or preB
receptor) with functional signaling capacity. The
administration of numerous mutations into the mouse
germline enabled us to identify several checkpoints
along the B cell developmental pathway, and provided
us with powerful experimental tools to probe for
selection events regulating developmental progression.
In here, we will discuss recent studies in this field.
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Citation
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