Publication:
Long non-coding RNA SNHG7 promotes malignant melanoma progression through negative modulation of miR-9

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dc.contributor.authorWang, Wendi
dc.contributor.authorLiu, Guangjing
dc.contributor.authorLiu, Man
dc.contributor.authorLi, Xiaobing
dc.date.accessioned2022-12-07T09:03:21Z
dc.date.available2022-12-07T09:03:21Z
dc.date.issued2020
dc.description.abstractLong non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) was verified to act as an onco- gene in human cancers. Nevertheless, the role of SNHG7 in malignant melanoma remains elusive. The present study showed an increase of SNHG7 expression in malignant melanoma tissues and cell lines. Besides, SNHG7 knockdown inhibited proliferation and migration in malignant melanoma cells. Bioinformatics analysis demonstrated that SNHG7 functions as a molecular sponge for miR-9 in biological behavior of melanoma cells. And miR-9 could inhibit the expression of PI3KR3 by binding with the 3’ -UTR. Furthermore, PI3KR3, pAKT, cyclin D1 and Girdin expression was down-regulated after SNHG7 knockdown by siRNA. In addition, SNHG7 knockdown decreased xenograft growth in vivo. Taken together, this research demonstrated that SNHG7 was an oncogene in malignant melanoma, providing a novel insight for the pathogenesis and new potential therapeutic target for malignant melanoma.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 35, nº9 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-225
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126208
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMalignant melanomaes
dc.subjectSNHG7es
dc.subjectmiR-9es
dc.subjectPI3K/AKT signaling pathwayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleLong non-coding RNA SNHG7 promotes malignant melanoma progression through negative modulation of miR-9es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº9 (2020)