Publication: Long non-coding RNA SNHG7 promotes malignant melanoma progression through negative modulation of miR-9
Authors
Wang, Wendi ; Liu, Guangjing ; Liu, Man ; Li, Xiaobing
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-225
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info:eu-repo/semantics/article
Description
Abstract
Long non-coding small nucleolar RNA host
gene 7 (lncRNA SNHG7) was verified to act as an onco-
gene in human cancers. Nevertheless, the role of SNHG7
in malignant melanoma remains elusive. The present
study showed an increase of SNHG7 expression in
malignant melanoma tissues and cell lines. Besides,
SNHG7 knockdown inhibited proliferation and
migration in malignant melanoma cells. Bioinformatics
analysis demonstrated that SNHG7 functions as a
molecular sponge for miR-9 in biological behavior of
melanoma cells. And miR-9 could inhibit the expression
of PI3KR3 by binding with the 3’ -UTR. Furthermore,
PI3KR3, pAKT, cyclin D1 and Girdin expression was
down-regulated after SNHG7 knockdown by siRNA. In
addition, SNHG7 knockdown decreased xenograft
growth in vivo. Taken together, this research
demonstrated that SNHG7 was an oncogene in
malignant melanoma, providing a novel insight for the
pathogenesis and new potential therapeutic target for
malignant melanoma.
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Citation
Histology and Histopathology Vol. 35, nº9 (2020)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/