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Circulating blood biomarkers correlated with the prognosis of advanced triple negative breast cancer

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dc.contributor.authorLi, Xingyu
dc.contributor.authorZhang, Yanyan
dc.contributor.authorZhu, Cheng
dc.contributor.authorXu, Wentao
dc.contributor.authorHu, Xiaolei
dc.contributor.authorSánchez Martínez, Domingo Antonio
dc.contributor.authorAlonso Romero, José Luis
dc.contributor.authorYan, Ming
dc.contributor.authorDai, Ying
dc.contributor.authorWang, Hua
dc.contributor.departmentMedicina
dc.date.accessioned2024-11-05T11:39:15Z
dc.date.available2024-11-05T11:39:15Z
dc.date.issued2024-01-13
dc.description© The Author(s) 2024. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in BMC Women's Health. To access the final edited and published work see https://doi.org/10.1186/s12905-023-02871-6
dc.description.abstractBackground Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy of ICIs. Materials and methods In this study, we analyzed the data of ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 to 2023. The counts of lymphocytes, monocytes, platelets, and ratio indexes (NLR, MLR, PLR) in peripheral blood were investigated via the Kaplan-Meier curves and the Cox proportional-hazards model. Results The total of 50 mTNBC patients were treated with ICIs. High level of peripheral lymphocytes and low level of NLR and MLR at baseline and post the first cycle of ICIs play the predictable role of immunotherapies. Lymphocytes counts (HR = 0.280; 95% CI: 0.095–0.823; p = 0.021) and NLR (HR = 1.150; 95% CI: 1.052–1.257; p = 0.002) are significantly correlated with overall survival. High NLR also increases the risk of disease progression (HR = 2.189; 95% CI:1.085–4.414; p = 0.029). When NLR at baseline ≥ 2.75, the hazard of death (HR = 2.575; 95% CI:1.217–5.447; p = 0.013) and disease progression (HR = 2.189; 95% CI: 1.085–4.414; p = 0.029) significantly rise. HER-2 expression and anti-tumor therapy lines are statistically correlated with survivals. Conclusions Before the initiation of ICIs, enriched peripheral lymphocytes and poor neutrophils and NLR contribute to the prediction of survivals.es
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dc.format.extent9es
dc.identifier.citationBMC Women's Health, , 2024, Vol. 24 (1): 38
dc.identifier.doihttps://doi.org/10.1186/s12905-023-02871-6
dc.identifier.issnElectronic: 1472-6874
dc.identifier.urihttp://hdl.handle.net/10201/146002
dc.languageenges
dc.publisherBioMed Central
dc.relationThis work was supported by the grant from Anhui Natural Science Foundation Youth Program (2008085QH424) and Basic and Applied Basic Research Fund of Guangdong Province (2019A1515011331).es
dc.relation.publisherversionhttps://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-023-02871-6
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTriple negative breast canceres
dc.subjectPeripheral blood cell countes
dc.subjectAnti PD 1es
dc.subjectImmunotherapyes
dc.subjectImmune checkpoint inhibitorses
dc.titleCirculating blood biomarkers correlated with the prognosis of advanced triple negative breast canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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