Publication: Circulating blood biomarkers correlated with the prognosis of advanced triple negative breast cancer
Authors
Li, Xingyu ; Zhang, Yanyan ; Zhu, Cheng ; Xu, Wentao ; Hu, Xiaolei ; Sánchez Martínez, Domingo Antonio ; Alonso Romero, José Luis ; Yan, Ming ; Dai, Ying ; Wang, Hua
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Publisher
BioMed Central
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DOI
https://doi.org/10.1186/s12905-023-02871-6
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info:eu-repo/semantics/article
Description
© The Author(s) 2024. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published version of a Published Work that appeared in final form in BMC Women's Health. To access the final edited and published work see https://doi.org/10.1186/s12905-023-02871-6
Abstract
Background
Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy of ICIs.
Materials and methods
In this study, we analyzed the data of ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 to 2023. The counts of lymphocytes, monocytes, platelets, and ratio indexes (NLR, MLR, PLR) in peripheral blood were investigated via the Kaplan-Meier curves and the Cox proportional-hazards model.
Results
The total of 50 mTNBC patients were treated with ICIs. High level of peripheral lymphocytes and low level of NLR and MLR at baseline and post the first cycle of ICIs play the predictable role of immunotherapies. Lymphocytes counts (HR = 0.280; 95% CI: 0.095–0.823; p = 0.021) and NLR (HR = 1.150; 95% CI: 1.052–1.257; p = 0.002) are significantly correlated with overall survival. High NLR also increases the risk of disease progression (HR = 2.189; 95% CI:1.085–4.414; p = 0.029). When NLR at baseline ≥ 2.75, the hazard of death (HR = 2.575; 95% CI:1.217–5.447; p = 0.013) and disease progression (HR = 2.189; 95% CI: 1.085–4.414; p = 0.029) significantly rise. HER-2 expression and anti-tumor therapy lines are statistically correlated with survivals.
Conclusions
Before the initiation of ICIs, enriched peripheral lymphocytes and poor neutrophils and NLR contribute to the prediction of survivals.
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Citation
BMC Women's Health, , 2024, Vol. 24 (1): 38
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/