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Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients

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dc.contributor.authorMartínez Banaclocha, Helios
dc.contributor.authorGarcía Palenciano, Carlos
dc.contributor.authorMartínez Alarcón, Laura
dc.contributor.authorAmores Iniesta, Joaquín
dc.contributor.authorErcole, Giovanni A.
dc.contributor.authorGonzález Lisorge, Ada
dc.contributor.authorFernánde Pacheco, José
dc.contributor.authorMartínez Gil, Piedad
dc.contributor.authorPadilla Rodríguez, Julio
dc.contributor.authorBaroja Mazo, Alberto
dc.contributor.authorMartínez García, Juan José
dc.contributor.authorMartín Sánchez, María Rosario Fátima
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.departmentSanidad Animal
dc.date.accessioned2024-10-18T06:44:38Z
dc.date.available2024-10-18T06:44:38Z
dc.date.issued2023-11-29
dc.description© The Authors 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in Frontiers in Immunology. To access the final edited and published work see https://doi.org/10.3389/fimmu.2023.1297249es
dc.description.abstractInflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relationship between the percentage of P2X7-expressing lymphocytes and the early inflammatory response in sepsis. Additionally, in patients whose lymphocytes presented a higher percentage of P2X7 surface expression, the total lymphocytes populations proportionally decreased. Furthermore, we found a correlation between elevated soluble P2X7 receptors in plasma and inflammasome-dependent cytokine IL-18. In summary, our work demonstrates that P2X7 expression is highly induced in lymphocytes during sepsis, and this correlates with IL-18, along with other inflammatory mediators such as IL-6, IL-8, and procalcitonin.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.doihttps://doi.org/10.3389/fimmu.2023.1297249
dc.identifier.eisbnFrontiers in Immunology, 2023, Vol. 14 : 1297249es
dc.identifier.issnElectronic: 1664-3224
dc.identifier.urihttp://hdl.handle.net/10201/145400
dc.languageenges
dc.publisherFrontiers Mediaes
dc.relationThis work received support from grants awarded to PP from MCIN/AEI (grant PID2020-116709RB-I00), Fundación Séneca (grants 20859/PI/18, 21081/PDC/19, and 21897/PI/22), the Instituto Salud Carlos III (grants DTS21/00080 and AC22/00009), and the European Research Council (grant ERC-2019-PoC 899636). JJM-G received a grant from Fundación Séneca (grant 21967/JLI/22) and was supported by the Maria Zambrano grant from the University of Murcia.es
dc.relation.publisherversionhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1297249/fulles
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSepsises
dc.subjectInflammationes
dc.subjectP2X7 receptores
dc.subjectPurinergic signalinges
dc.subjectDanger signalses
dc.subjectLeukocyteses
dc.titlePurinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patientses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationeefc2e40-b110-47b5-a081-bcf37256af4c
relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication.latestForDiscoveryeefc2e40-b110-47b5-a081-bcf37256af4c
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