Publication: Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients
Authors
Martínez Banaclocha, Helios ; García Palenciano, Carlos ; Martínez Alarcón, Laura ; Amores Iniesta, Joaquín ; Ercole, Giovanni A. ; González Lisorge, Ada ; Fernánde Pacheco, José ; Martínez Gil, Piedad ; Padilla Rodríguez, Julio ; Baroja Mazo, Alberto ; Martínez García, Juan José ; Martín Sánchez, María Rosario Fátima ; Pelegrín Vivancos, Pablo
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Frontiers Media
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DOI
https://doi.org/10.3389/fimmu.2023.1297249
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info:eu-repo/semantics/article
Description
© The Authors 2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published version of a Published Work that appeared in final form in Frontiers in Immunology. To access the final edited and published work see https://doi.org/10.3389/fimmu.2023.1297249
Abstract
Inflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relationship between the percentage of P2X7-expressing lymphocytes and the early inflammatory response in sepsis. Additionally, in patients whose lymphocytes presented a higher percentage of P2X7 surface expression, the total lymphocytes populations proportionally decreased. Furthermore, we found a correlation between elevated soluble P2X7 receptors in plasma and inflammasome-dependent cytokine IL-18. In summary, our work demonstrates that P2X7 expression is highly induced in lymphocytes during sepsis, and this correlates with IL-18, along with other inflammatory mediators such as IL-6, IL-8, and procalcitonin.
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