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Modulatory role of IL10 in endothelial cell damage and platelet adhesion

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dc.contributor.authorGimeno, M.J.es
dc.contributor.authorPascual, G.es
dc.contributor.authorGarcía-Honduvilla, N.
dc.contributor.authorPrieto, A.
dc.contributor.authorAlvarez de Mon, M.
dc.contributor.authorBellón, J.M.
dc.contributor.authorBuján, J.
dc.date.accessioned2011-06-08T09:03:46Z
dc.date.available2011-06-08T09:03:46Z
dc.date.issued2003
dc.description.abstractThis study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultures and allowed to act for 30 minutes. To rule out blood plasma involvement, washed platelets were also incubated with IL-10 (0-100 ng/ml). Changes in endothelial cell morphology were observed depending on the IL-10 concentration used; apoptotic cells appearing at the highest IL-10 concentration. Greatest platelet adhesion was noted at the highest IL-10 concentration. It was concluded that, in this in vitro model, low IL-10 levels do not affect cell viability or the pattern of platelet adhesion, but at high doses, this cytokine induces cell death and enhances platelet deposition.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21475
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEndothelial cellses
dc.subjectPlateletes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleModulatory role of IL10 in endothelial cell damage and platelet adhesiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.18, nº 3 (2003)