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Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography

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dc.contributor.authorGrulkowski, Ireneusz
dc.contributor.authorManzanera, Silvestre
dc.contributor.authorCwiklinski, Lukasz
dc.contributor.authorMompeán, Juan
dc.contributor.authorCastro, Alberto de
dc.contributor.authorMarín Sánchez, José María
dc.contributor.authorArtal, Pablo
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2025-01-26T09:42:08Z
dc.date.available2025-01-26T09:42:08Z
dc.date.issued2018-07-24
dc.description© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Biomedical Optics Express. To access the final edited and published work see https://doi.org/10.1364/BOE.9.003821
dc.description.abstractWe demonstrate an optimized optical platform for the three-dimensional (3-D) visualization of crystalline lens opacities in vivo in the eyes of patients with different types and grades of cataracts. We developed a prototype long-depth-range swept source optical coherence tomography (SS-OCT) instrument operating at the speed of 50 kA-scans/second and at the central wavelength of 1 μm to perform high-resolution imaging of the whole anterior segment of the eye. Volumetric data sets of cataractous eyes were acquired and processed to obtain contrast-enhanced high-resolution images of lenticular structures and opacifications. The results showed lens micro- and macro-scale features related to possible cataract development such as cortical spokes, water clefts and enhanced scattering in the lens nucleus. The results demonstrate also the ability of this SS-OCT imaging to locate and characterize opacities quantitatively. The instrument might be a useful tool in the high-resolution preoperative evaluation of crystalline lens opacities in cataract patients.
dc.formatapplication/pdfes
dc.format.extent13
dc.identifier.citationBiomedical Optics Express, 2018, Vol. 9, Issue 8, pp. 3821-3833
dc.identifier.doihttps://doi.org/10.1364/BOE.9.003821
dc.identifier.issnElectronic: 2156-7085
dc.identifier.urihttp://hdl.handle.net/10201/149285
dc.languageenges
dc.publisherOptica Publishing Group
dc.relationEuropean Research Council Advanced Grant (SEECAT, #ERC-2013-AdG-339228); Secretaría de Estado de Investigación, Desarrollo e Innovación (SEIDI; #FIS2016-76163-R); Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia (#19897/GERM/15); European Regional Development Fund (#EU-FEDER); Polish Ministry of Science and Higher Education (Ministerstwo Nauki i Szkolnoctwa Wyższego; #IP2014 014073); Scholarship of the Polish Ministry for Science and Higher Education.es
dc.relation.publisherversionhttps://opg.optica.org/boe/fulltext.cfm?uri=boe-9-8-3821&id=395627
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDynamic light scattering
dc.subjectImaging systems
dc.subjectMagnetic resonance imaging
dc.subjectSwept sources
dc.subjectSystems design
dc.subjectX ray imaging
dc.titleVolumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomographyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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