Publication:
Volumetric macro- and micro-scale assessment of crystalline lens opacities in cataract patients using long-depth-range swept source optical coherence tomography

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2018_BioOptExp_Volumetric_Grulkowski.pdf(4.04 MB)
Date
2018-07-24
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Authors
Grulkowski, Ireneusz ; Manzanera, Silvestre ; Cwiklinski, Lukasz ; Mompeán, Juan ; Castro, Alberto de ; Marín Sánchez, José María ; Artal, Pablo
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Publisher
Optica Publishing Group
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publication.page.department
Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
DOI
https://doi.org/10.1364/BOE.9.003821
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info:eu-repo/semantics/article
Description
© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Biomedical Optics Express. To access the final edited and published work see https://doi.org/10.1364/BOE.9.003821
Abstract
We demonstrate an optimized optical platform for the three-dimensional (3-D) visualization of crystalline lens opacities in vivo in the eyes of patients with different types and grades of cataracts. We developed a prototype long-depth-range swept source optical coherence tomography (SS-OCT) instrument operating at the speed of 50 kA-scans/second and at the central wavelength of 1 μm to perform high-resolution imaging of the whole anterior segment of the eye. Volumetric data sets of cataractous eyes were acquired and processed to obtain contrast-enhanced high-resolution images of lenticular structures and opacifications. The results showed lens micro- and macro-scale features related to possible cataract development such as cortical spokes, water clefts and enhanced scattering in the lens nucleus. The results demonstrate also the ability of this SS-OCT imaging to locate and characterize opacities quantitatively. The instrument might be a useful tool in the high-resolution preoperative evaluation of crystalline lens opacities in cataract patients.
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Dynamic light scattering , Imaging systems , Magnetic resonance imaging , Swept sources , Systems design , X ray imaging
Citation
Biomedical Optics Express, 2018, Vol. 9, Issue 8, pp. 3821-3833
URI
http://hdl.handle.net/10201/149285
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