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Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: Evidence from a randomized double- blind clinical trial

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dc.contributor.authorSánchez Barrueco, Álvaro
dc.contributor.authorMateos-Moreno, Maria Victoria
dc.contributor.authorMartínez- Beneyto, Yolanda
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.authorCampos González, Alfonso
dc.contributor.authorZapardiel Ferrero, Javier
dc.contributor.authorBogoya Castaño, Abel
dc.contributor.authorAlcalá Rueda, Ignacio
dc.contributor.authorVillacampa Aubá, José Miguel
dc.contributor.authorCenjor Español, Carlos
dc.contributor.authorMoreno-Parrado, Laura
dc.contributor.authorAusina- Márquez, Verónica
dc.contributor.authorGarcía-Esteban, Sandra
dc.contributor.authorArtacho, Alejandro
dc.contributor.authorLópez- Labrador, F. Xavier
dc.contributor.authorMira, Alex
dc.contributor.authorFerrer, María D.
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-20T08:27:06Z
dc.date.available2024-06-20T08:27:06Z
dc.date.issued2022-07-27
dc.description©2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ . This document is the Accepted, version of a Published Work that appeared in final form in Emerging Microbes & Infections. To access the final edited and published work see https://doi.org/10.1080/22221751.2022.2098059es
dc.description.abstractBackground: In vitro studies have shown that several oral antiseptics have virucidal activity against SARS-CoV-2. Thus, mouthwashes have been proposed as an easy to implement strategy to reduce viral transmission. However, there are no data measuring SARS-CoV-2 viability after mouthwashes in vivo. Methods: In this randomized double-blind, five-parallel-group, placebo-controlled clinical trial, SARS-CoV-2 salivary viral load (by quantitative PCR) and its infectious capacity (incubating saliva in cell cultures) have been evaluated before and after four different antiseptic mouthwashes and placebo in 54 COVID-19 patients. Results: Contrary to in vitro evidence, salivary viral load was not affected by any of the four tested mouthwashes. Viral culture indicated that cetylpyridinium chloride (CPC) significantly reduced viral infectivity, but only at one-hour post-mouthwash. Conclusion: These results indicate that some of the mouthwashes currently used to reduce viral infectivity are not efficient in vivo and, furthermore, that this effect is not immediate, generating a false sense of security.es
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dc.format.extent23es
dc.identifier.citationEmerging Microbes & Infections. 2022, Vol. 11(1): 1833-1842
dc.identifier.doihttps://doi.org/10.1080/22221751.2022.2098059
dc.identifier.eissnElectronic: 2222-1751
dc.identifier.urihttp://hdl.handle.net/10201/142485
dc.languageenges
dc.publisherTaylor and Francis Groupes
dc.relationFISABIO-Public Health BSL-3, supported by the Conselleria de Sanitat, Generalitat Valenciana and by the European Union Regional Development Fund. Biobank Network of the Region of Murcia, BIOBANC-MUR (B.0000859), supported by the Instituto de Salud Carlos III (proyecto PT20/00109), by Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB) and by Conserjería de Salud de la Comunidad Autónoma de la Región de Murciaes
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/22221751.2022.2098059es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSARS-CoV-2es
dc.subjectSalivaes
dc.subjectCOVID-19es
dc.subjectInfectivityes
dc.subjectMouthwases
dc.titleEffect of oral antiseptics in reducing SARS-CoV-2 infectivity: Evidence from a randomized double- blind clinical triales
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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