Publication: Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: Evidence from a randomized double- blind clinical trial
Authors
Sánchez Barrueco, Álvaro ; Mateos-Moreno, Maria Victoria ; Martínez- Beneyto, Yolanda ; García-Vázquez, Elisa ; Campos González, Alfonso ; Zapardiel Ferrero, Javier ; Bogoya Castaño, Abel ; Alcalá Rueda, Ignacio ; Villacampa Aubá, José Miguel ; Cenjor Español, Carlos ; Moreno-Parrado, Laura ; Ausina- Márquez, Verónica ; García-Esteban, Sandra ; Artacho, Alejandro ; López- Labrador, F. Xavier ; Mira, Alex ; Ferrer, María D.
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Publisher
Taylor and Francis Group
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DOI
https://doi.org/10.1080/22221751.2022.2098059
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info:eu-repo/semantics/article
Description
©2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ . This document is the Accepted, version of a Published Work that appeared in final form in Emerging Microbes & Infections. To access the final edited and published work see https://doi.org/10.1080/22221751.2022.2098059
Abstract
Background: In vitro studies have shown that several oral antiseptics have virucidal activity against SARS-CoV-2. Thus, mouthwashes have been proposed as an easy to implement strategy to reduce viral transmission. However, there are no data measuring SARS-CoV-2 viability after mouthwashes in vivo. Methods: In this randomized double-blind, five-parallel-group, placebo-controlled clinical trial, SARS-CoV-2 salivary viral load (by quantitative PCR) and its infectious capacity (incubating saliva in cell cultures) have been evaluated before and after four different antiseptic mouthwashes and placebo in 54 COVID-19 patients. Results: Contrary to in vitro evidence, salivary viral load was not affected by any of the four tested mouthwashes. Viral culture indicated that cetylpyridinium chloride (CPC) significantly reduced viral infectivity, but only at one-hour post-mouthwash. Conclusion: These results indicate that some of the mouthwashes currently used to reduce viral infectivity are not efficient in vivo and, furthermore, that this effect is not immediate, generating a false sense of security.
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Citation
Emerging Microbes & Infections. 2022, Vol. 11(1): 1833-1842
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