Publication: T cell regulation of the immune response to infection in periodontal diseases
Authors
Yamazaki, K. ; Yoshie, H. ; Seymour, G.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although T cells have been implicated in the
pathogenesis and are considered to be central both in
progression and control of the chronic inflammatory
periodontal diseases, the precise contribution of T cells
to the regulation of tissue destruction has not been fully
elucidated. Current dogma suggests that immunity to
infection is controlled by distinct T helper 1 (Th1) and T
helper 2 (Th2) subsets of T cells classified on the basis
of their cytokine profile. Further, a subset of T cells with
immunosuppressive function and cytokine profile
distinct from Th1 or Th2 has been described and
designated as regulatory T cells. Although these
regulatory T cells have been considered to maintain selftolerance
resulting in the suppression of auto-immune
responses, recent data suggest that these cells may also
play a role in preventing infection-induced
immunopathology. In this review, the role of functional
and regulatory T cells in chronic inflammatory
periodontal diseases will be summarized. This should
not only provide an insight into the relationship between
the immune response to periodontopathic bacteria and disease but should also highlight areas of development
for potentially new therapeutic modalities.
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