Publication: Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas
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Date
1992
Authors
Gottschalk, J. ; Goebel, S. ; Jautzke, G. ; Martín, H. ; Zimmer, C. ; Marzheuser-Brands, S. ; Cervós-Navarro, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We conducted a trial in 42 benign and
malignant meningiomas to assess a possible influence of
preoperative dexamethasone therapy on mitotic index,
labelling indices of proliferating cell nuclear antigen
(PCNA), progesterone receptor, epidermal growth factor
receptor (EGF-R), c-erbB-2 oncoprotein, cathepsin D,
gamma-gamma enolase as well as the mean number of
silver-stained nucleolar organizer region-associated
proteins (AgNORs). Tumors with preceding
dexamethasone therapy for more than 1 day display
significantly less immunohistochemical staining for
PCNA. A correlation between the labelling index of
PCNA and the degree of malignancy could not be
identified. There was no significant effect of
preoperative dexamethasone therapy on the other
parameters. Our data suggest that dexarnethasone may
selectively inhibit the expression of PCNA in the GlISphase
of the cell cycle. Thus, we emphasize the
necessity to heed factors, e.g. dexamethasone, which
may affect the expression of proliferating markers.
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Citation
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