Publication: Nickel-catalyzed chemo-, regio- and diastereoselective bond formation through proximal C-C cleavage of benzocyclobutenones
Authors
Juliá Hernández, Francisco ; Ziadi, Asraa ; Nishimura, Akira ; Martin, Ruben
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Publisher
Wiley, Gesellschaft Deutscher Chemiker
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DOI
https://doi.org/10.1002/anie.201503461
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info:eu-repo/semantics/article
Description
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted version of a Published Work that appeared in final form in Angewandte Chemie International Edition. To access the final edited and published work see https://doi.org/10.1002/anie.201503461
Abstract
The first catalytic intermolecular proximal C1-C2 cleavage of Benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo-, regio- and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons.
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Citation
Angew. Chem. Int. Ed. 2015, 54, 9537-9541
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