Publication: Pineal gland in rats with 7,12-dimethylbenz (a)
anthracene-induced mammary tumors subjected to
manipulations known as enhancers of pineal actions
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Date
1989
Authors
Cos, S. ; Bardasano, J. L. ; Mediavilla, M. D. ; Sánchez Barceló, E. J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ultrastructure of pinealocytes was
studied in rats with 7,17-dimethylbenz (a) anthraceneinduced
manimary tumors which were subjected to
experimental manipulations known as enhancers of
pineal actions (anosmia, underfeeding or cold
exposure). In these aniinals we found: (1) - more nuclei
with deep nuclear invaginations; (11) - a large number
of cytoplasmic organelles, including lipid droplets.
myeloid bodies, synaptic ribbons and lysosomes; (111) -
numerous degenerative changes. In general, we found an
increase in structural features related to pineal
photoneuroendocrine activity. Our results indicate that
pineal-dependent inhibition of neoplastic growth
induced by these experimental manipulations,
previously reported, can be mediated through an
increase in pineal metabolic activity.
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