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Effect of dolomite on the repair of bone defects in rats; histological study

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dc.contributor.authorMoreschi, Eduardoes
dc.contributor.authorHernandes, Luzmarinaes
dc.contributor.authorAraujo Dantas, Jailson
dc.contributor.authorRaffaini Covas Pereira da Silva, Maria Angélica
dc.contributor.authorCasaroto, Ana Regina
dc.contributor.authorBersani-Amado, Ciomar Aparecida
dc.date.accessioned2015-09-29T07:19:07Z
dc.date.available2015-09-29T07:19:07Z
dc.date.issued2010
dc.description.abstractThe aim of the present study was to evaluate histologically and radiographically the tissue response to dolomite [CaMg(CO3)2] and its osteogenic potential in the repair of bone cavities in the calvaria of rats. A bone defect 10 mm in diameter and 1 mm deep was made in the calvaria of male Wistar rats. The defects were filled with dolomite, inorganic bovine bone (positive control), or coagulum (negative control). The animals were euthanized 7, 15, 30, and 60 days after surgery, and specimens were collected for radiographic and microscopic analyses. The bone defects were processed for paraffin embedding and H&E staining. The histological study revealed that dolomite stimulated a moderate inflammatory response, with programmed cell death in the first 15 days, compared to bovine bone which showed a moderate to intense acute response. In the chronic phase, the inflammatory response was characterized by the occurrence of macrophages organized as epithelioid cells in the dolomite group, and giant cells in the bovine-bone group. Fibrosis developed in all three groups; however, encapsulation of the fragments, reabsorption, and osteoconductive activity occurred only in the defects filled with bovine bone. The radiographic analysis showed that the bovine bone was most efficient in the repair of the defects, followed by the dolomite and the coagulum. This study demonstrated that the dolomite stimulated a moderate acute inflammatory response with programmed cell death, and a chronic inflammatory response by means of the phagocytic mononuclear system. Although osteoconductive activity was not shown, the dolomite favored the repair process, compared to the coagulum group.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46375
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDolomitees
dc.subjectInorganic bovine bonees
dc.subject.other61 - Medicinaes
dc.titleEffect of dolomite on the repair of bone defects in rats; histological studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25,nº12 (2010)