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Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma

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dc.contributor.authorLi, Xiao-Han
dc.contributor.authorNoguchi, Akira
dc.contributor.authorNishida, Takeshi
dc.contributor.authorTakahashi, Hiroyuki
dc.contributor.authorZheng, Yang
dc.contributor.authorYang, Xiang-Hong
dc.contributor.authorMasuda, Shinji
dc.contributor.authorKikuchi, Keiji
dc.contributor.authorTakano, Yasuo
dc.coverage.temporal1996-2006es
dc.date.accessioned2016-04-18T08:43:25Z
dc.date.available2016-04-18T08:43:25Z
dc.date.issued2011
dc.description.abstractSummary. To clarify the role of p33ING1b in tumorigenesis and progression of head and neck squamous cell carcinoma (HNSCC), we examined the expression and subcellular localization of p33ING1b in 214 HNSCC cases in parallel with 60 dysplasia samples and 48 normal epithelium samples by immunohistochemistry, and analyzed correlations of expression of p33ING1b in HNSCC cases with clinicopathological variables, apototic index and expression of 14-3-3η, p300, p21 and PCNA. Although 12% of HNSCC cases lost expression of p33ING1b, most cases of HNSCC retained expression of p33ING1b with levels similar to those in non-cancerous epithelia. Nuclear expression of p33ING1b was significantly decreased in HNSCC compared to normal epithelia. In contrast, cytoplasmic expression of p33ING1b was found to be significantly higher in HNSCC. An abundance of p33ING1b in cytoplasm positively correlated with poor differentiation and tumor progression. Corresponding to those clinicopathogical features, high expression of p33ING1b in the cytoplasm correlated with PCNA labelling index but in contrast, that in the nuclei correlated with apoptosis. In nuclei, p33ING1b is coexpressed with p300 and p21, implying its roles in tumor suppression. Elevated expression of 14-3-3η was associated with cytoplasmic expression of p33ING1b and immunofluorescence study suggested association of p33ING1b and 14-3-3η. Among three cell lines derived from oral SCC, poorly-differentiated SAS cells showed a relatively high expression of p33ING1b in cytoplasm withes
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/48626
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and Histopathology,vol.26, nº5, 2011es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectp33ING1bes
dc.subject14-3-3ηes
dc.subjectHNSCCes
dc.subject.other61 - Medicinaes
dc.titleCytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº5 (2011)