Publication: Cytoplasmic expression of p33ING1b is
correlated with tumorigenesis and progression
of head and neck squamous cell carcinoma
Authors
Li, Xiao-Han ; Noguchi, Akira ; Nishida, Takeshi ; Takahashi, Hiroyuki ; Zheng, Yang ; Yang, Xiang-Hong ; Masuda, Shinji ; Kikuchi, Keiji ; Takano, Yasuo
item.page.secondaryauthor
item.page.director
Publisher
Murcia: F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Summary. To clarify the role of p33ING1b in
tumorigenesis and progression of head and neck
squamous cell carcinoma (HNSCC), we examined the
expression and subcellular localization of p33ING1b in
214 HNSCC cases in parallel with 60 dysplasia samples
and 48 normal epithelium samples by immunohistochemistry,
and analyzed correlations of expression
of p33ING1b in HNSCC cases with clinicopathological
variables, apototic index and expression of 14-3-3η,
p300, p21 and PCNA. Although 12% of HNSCC cases
lost expression of p33ING1b, most cases of HNSCC
retained expression of p33ING1b with levels similar to
those in non-cancerous epithelia. Nuclear expression of
p33ING1b was significantly decreased in HNSCC
compared to normal epithelia. In contrast, cytoplasmic
expression of p33ING1b was found to be significantly
higher in HNSCC. An abundance of p33ING1b in
cytoplasm positively correlated with poor differentiation
and tumor progression. Corresponding to those
clinicopathogical features, high expression of p33ING1b
in the cytoplasm correlated with PCNA labelling index
but in contrast, that in the nuclei correlated with
apoptosis. In nuclei, p33ING1b is coexpressed with p300
and p21, implying its roles in tumor suppression.
Elevated expression of 14-3-3η was associated with
cytoplasmic expression of p33ING1b and
immunofluorescence study suggested association of
p33ING1b and 14-3-3η. Among three cell lines derived
from oral SCC, poorly-differentiated SAS cells showed a
relatively high expression of p33ING1b in cytoplasm with
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.