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Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration

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dc.contributor.authorNavone, Stefania Elena
dc.contributor.authorMarfia, Giovanni
dc.contributor.authorGiannoni, Amedeo
dc.contributor.authorBeretta, Matteo
dc.contributor.authorGuarnaccia, Laura
dc.contributor.authorGualtierotti, Roberta
dc.contributor.authorNicoli, Daniele
dc.contributor.authorRampini, Paolo
dc.contributor.authorCampanella, Rolando
dc.date.accessioned2022-02-22T12:29:58Z
dc.date.available2022-02-22T12:29:58Z
dc.date.issued2017
dc.description.abstractIntervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a condition that represents a serious socio-economic burden. Deeper knowledge of the complex and fine relationship between IVD degeneration, tissue inflammation and pain, appears to be critical to improve the current therapies, which have so far proven themselves ineffective. Upon degeneration, IVD tissues become inflamed, and this inflammatory microenvironment is associated with a cascade of degenerative events that may eventually cause discogenic pain. In particular, several studies have highlighted the major role of a number of proinflammatory mediators not only in the onset of the inflammatory condition, but also in the development of IDD in general. In this review, we will present the main pathological events that occur during disc degeneration, focusing on the relationship between the abnormal inflammatory milieu of the degenerating IVD, IDD and the generation of pain. Finally, we will present the current therapies for the treatment of IDD and low back pain, and the perspectives of future, more effective therapies.es
dc.formatapplication/pdfes
dc.format.extent20es
dc.identifier.citationHistology and Histopathology, Vol.32, nÂş6, (2017)
dc.identifier.doiDOI 10.14670/HH-11-846
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117227
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIntervertebral disc degenerationes
dc.subjectInflammatory mediatorses
dc.subjectLow back paines
dc.subjectNeuroinflammationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleInflammatory mediators and signalling pathways controlling intervertebral disc degenerationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nÂş6 (2017)